Endocrine disruptor induction of epigenetic transgenerational inheritance of disease
نویسندگان
چکیده
منابع مشابه
Endocrine disruptor vinclozolin induced epigenetic transgenerational adult-onset disease.
The fetal basis of adult disease is poorly understood on a molecular level and cannot be solely attributed to genetic mutations or a single etiology. Embryonic exposure to environmental compounds has been shown to promote various disease states or lesions in the first generation (F1). The current study used the endocrine disruptor vinclozolin (antiandrogenic compound) in a transient embryonic e...
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Recent fi ndings in the emerging fi eld of transgenerational epigenetic inheritance suggest that the lifestyle choices and experiences of an individual have biological implications for offspring not yet conceived. Studies show that diet, drugs, and even social experiences can lead to life-long changes in gene expression. Some changes in gene expression are passed down to future generations. The...
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Marisa Bartolomei University of Pennsylvania, USA Stefan Beck University College London, UK Christoph Bock University of Vienna, AT Liran Carmel Hebrew University of Jerusalem, IL Katharina Gapp Sanger Institute, Cambridge, UK Johannes Graeff Ecole Polytechnique Fédérale, Lausanne, CH Carlos Guerrero-Bosagna Linköping University, SE Eva Jablonka Tel Aviv University, IL Josep Chillarón Hospital ...
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Rapidly accumulating evidence shows that herbivore and pathogen attack of plants can generate particular defense phenotypes across generations. What was once thought to be an oddity of plant defense induction now appears to be a taxonomically widespread phenomenon with strong potential to impact the ecology and evolution of species interactions. DNA methylation, histone modifications, and small...
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with abiotic and biotic components of their surroundings. Whereas many and perhaps most of the encounters pass with transient changes at the molecular and metabolic levels, some have a profound impact on the phenotypic appearance of an organism and, more importantly, on the phenotypic appearance of their progeny. Since genetic changes are rare and random in nature, their influence on species or...
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ژورنال
عنوان ژورنال: Molecular and Cellular Endocrinology
سال: 2014
ISSN: 0303-7207
DOI: 10.1016/j.mce.2014.07.019